11-bravoThe concepts of Muscle Protein Synthesis (MPS) and Muscle Protein Breakdown (MPB) are well known among avid athletes. It is the interplay between the two that determines whether muscle mass is gained or lost. It was recently discovered that orally ingested phosphatidic acid (PA), when coupled with mechanical loading of muscles and adequate protein intake, significantly activates the mammalian Target of Rapamycin (mTOR) signalling pathway. mTOR regulates protein synthesis, translating ingested protein into new muscle. That's MPS. New scientific evidence suggests that PA may even reduce MPB. Mediator® Phosphatidic Acid (PA), our proprietary and patented ingredient compound, was shown in a university study to provide double muscle mass gain, increased strength and double fat mass loss in individuals engaged in weight-bearing exercise who consumed sufficient protein .
The science supporting phosphatidic acid relates to signalling by the mechanism known as the mammalian target of rapamycin (mTOR), which scientists believe is necessary for mechanical load-induced skeletal muscle growth (muscle hypertrophy) and consequent strength gains. Many published studies indicate that the lipid messenger PA plays a crucial role in this mechanical activation of mTOR signalling, which is why mTOR is currently a hot-button of research. To date, we have conducted a tremendous amount of research to validate Mediator® Phosphatidic Acid (PA) as safe and effective. Moreover, PA occurs naturally in small amounts in foods and is a legal dietary supplement and is not a banned substance.
Two published research studies prove that consumption of Mediator® Phosphatidic Acid, combined with resistance exercise, appears to have a positive benefit on strength improvement and muscle mass development in young subjects. The first study showed that subjects taking PA showed a 12.7% increase in squat strength and a 2.6% increase in fat-free mass (LBM), while subjects consuming the placebo showed a 9.3% improvement in squat strength and a 0.1% change in LBM. The second study showed that subjects consuming Mediator® PA saw double the muscle mass gain, increased strength and double the fat mass loss compared to those consuming the placebo. 11 BRAVO contains 750 mg of Mediator...Let the GAINS begin!
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